Dr. Melanie Martin

Dr. Melanie Martin

Associate Professor of Physics

Ph. D. (Yale, 2000)
Phone (office): (204)786-9442
Phone (lab): (204) 789-3472
Fax: (204)774-4134
U of W office: 3L21
E-Mail:
Web Site:  mri.uwinnipeg.ca (This page will open in a new window.)

COURSES (2011-2012):

• PHYS-3301 - Quantum Mechanics I
  (Winter 2012)
• PHYS-2102 - Scientific Computing I
  (Winter 2012)

Physics Demo Links (pages will open in new windows):

• http://chem107.chem.tamu.edu/brown/shockpages/photoelectric.html
• http://www.acts.tinet.ie/compoundanglesandcalcu_668.html
  (Compound Angles and calculations)
• LINK to PHYSICS DEMO VIDEOS
  (This page will open in a new window. The ball and cup demo is the first one on the list.)
• http://www.ap.stmarys.ca/demos/content/osc_and_waves/simple_
  harmonic_oscillator/simple_harmonic_oscillator.html
• http://positron.ps.uci.edu/~dkirkby/music/html/
  demos/SimpleHarmonicMotion/index.html

RESEARCH INTERESTS:

• As a physicist specializing in magnetic resonance imaging (MRI), I am developing a non-invasive, empirical method to diagnose Alzheimer's Disease and other central nervous systems disorders in their earliest stages. I am also using MRI to follow the effectiveness of treatment regimes over the course of time.
  Research Web Page:  mri.uwinnipeg.ca (This page will open in a new window.)

RECENT PUBLICATIONS and CONFERENCE PRESENTATIONS:

• Vincent TJ, Thiessen JD, Kurjewicz LM, Germscheid SL, Turner AJ, Zhilkin P, Alexander ME and Martin M, Longitudinal Brain Size Measurements in APP/PS1 Transgenic Mice, Magnetic Resonance Insights 2010:4 19-26.
• Thiessen JD, Collister K, Nafez S, Schellenberg AE, Buist R, Martin M, and Albensi BC. Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease. Brain Structure and Function (2010), 215:29-36.
• Odero GL, Oikawa K, Collister K, Grossman D, Thiessen JD, Motnenko A, Ge N, Martin M, Glazner GW, Albensi BC, and Schapansky J. Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease. Neuroscience 169 (2010), 532-543
• Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Kong J, Li X-M, and Martin M. Monitoring Demyelination in a Cuprizone Mouse Model with Longitudinal and Quantitative MRI Measurements. International Society for Magnetic Resonance in Medicine (ISMRM) 2010 Annual Meeting, Stockholm, 4512.
• Measuring myelin content in the cuprizone mouse model with quantitative MRI methods, Jonathan D. Thiessen, Yanbo Zhang, Handi Zhang, Lingyan Wang, Richard Buist, Jiming Kong, Xin-Min Li, and Melanie Martin, Manitoba Neuroscience Network’s June 14, 2010 meeting.
• Kurjewicz LM, Martin M, Buist R, Thiessen JD, Del Bigio MD. In Vivo Experimental Animal Magnetic Resonance Microscopy Centre. Interfaculty Graduate Student Science Poster Day, University of Manitoba, May 25, 2010.
• Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Kong J, Li X-M, and Martin M. Measuring myelin content in the corpus callosum of a cuprizone mouse model of demyelination with quantitative MRI methods. The University of Manitoba Faculty of Medicine Manitoba Health Research Poster Competition, June 1, 2010.
• MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR, Purkinje cell loss in experimental autoimmune encephalomyelitis, Neuroimage 48 (2009), 637-651.
• Thiessen, J.D., Zhang, Y., Zhang, H., Wang, L., Buist, R., Kong, J., Li, X.-M., and Martin, M. Correlation of Myelin Content to Quantitative MRI Parameters Using a Cuprizone Mouse Model of Demyelination. Canadian Association of Physicists Annual Congress: 2nd Place in Division of Medical and Biological Physics Student Paper Competition, Moncton, NB, 2009.
• McCrea R, Harder S, Martin M, Buist R, Nichol H, A comparison of rapid-scanning X-ray fluorescence mapping and magnetic resonance imaging to localize brain iron distribution, European Journal of Radiology, 68S (2008) S109–S113.
• Chavakula, V., Kim, A., Cardigan Smith, B.Schellenberg, A., Buist, R., Procissi, D., Zhang, X., Fraser, S. E., Jacobs, R. E., Martin, M., Readhead, C. In vivo studies of mog-induced EAE using VEPS, diffusion weighted and T2 imaging, Journal Of Neurochemistry 2008, 104s, 121.
• Ruffins SW, Martin M, Keough L, Troung S, Fraser SE, Jacobs RE, Landford R, Digital Three-Dimensional Atlas of Quail Development Using High-Resolution MRI, TSW Development and Embryology (2007) 2 47-59.
• Martin M, Reyes SD, Hiltner TD, Givogri MI, Tyszka JM, Fisher R, Campagnoni AT, Fraser SE, Jacobs RE, Readhead C. T2-weighted uMRI and Evoked Potential of the Visual System Measurements During the Development of Hypomyelinated Transgenic Mice, Neurochemical Research 32 (2): 159-165, 2007.
• Thiessen JD, Collister KA, Kurjewicz LM, Del Bigio MR, Albensi BC, Martin M. Magnetic Resonance Imaging and Behavioural Test Comparisons in a Mouse Model of Alzheimer's Disease, Physics in Canada 63 (3):134-137, 2007.
• Chavakula V, Cardigan Smith B, Schellenberg A, Buist R, Procissi D, Fraser SE, Jacobs RE, Martin M, Readhead C. “A Longitudinal Study of Myelin Oligodendrocyte Glyocoprotein (MOG)-Induced EAE Using Non-Invasive Imaging Techniques,” ISMRM 2007 annual meeting, Berlin, 2410.
• Thiessen JD, Collister KA, Kurjewicz LM, Readhead C, Del Bigio MR, Albensi BC, Martin M. Correlating Longitudinal In Vivo Images of Beta-Amyloid Plaques with Morris Water Maze Test Results in a Mouse Model of Alzheimer’s Disease. ISMRM2007 annual meeting, Berlin, 311.
• Martin M, Cardigan Smith B, Chavakula V, Schellenberg A, Kim A, Procissi D, Buist R, Readhead C, A Longitudinal Study of Myelin Oligodendryocyte Glycoprotein (MOG)-Induced EAE Using Non-Invasive Imaging Techniques, 90th Canadian Chemistry Conference and Exhibition, Winnipeg, 2007.
• Martin M, Thiessen JD, Collister KA, Kurjewicz LM, Readhead C, Del Bigio MR, Albensi BC. Longitudinal In Vivo Study of Alzheimer's Disease, Journal Of Neurochemistry 2007, 102s1:134.
• Kim A, Cardigan Smith B, Schellenberg A, Readhead C, Buist R, Martin M. Investigating MOG induced EAE with in vivo Diffusion Weighted Imaging, Journal Of Neurochemistry 2007, 102s1:121.
• Chavakula V, Martin M, Procissi D, Kim A, Zhang XW, Fraser SE, Jacobs RE and Readhead C, Longitudinal Studies of Myelin Oligodendrocyte Glycoprotein-induced EAE using Visually Evoked Potentials and Magnetic Resonance Imaging, Journal Of Neurochemistry 2007, 102s1:120.
• Martin M, Storey DW, Buist R, Balaban E. In Vivo Magnetic Resonance Imaging of Quail Embryo Brain, Canadian Association of Physics Congress, 2007.
• Thiessen JD, Collister KA, Kurjewicz LM, Del Bigio MR, Albensi BC, Martin M. Magnetic Resonance Imaging and Behavioural Test Comparisons in a Mouse Model of Alzheimer's Disease, Canadian Association of Physics Congress, 2007.
• McCrea R, Harder S, Mousseau D, Martin M, Buist R, Nichol H, Optimizing Magnetic Resonance to Image Brain Metals: Correlating MR with X-ray Fluorescence Spectroscopic Imaging in a Model of Alzheimer’s Disease, Canadian Light Source Users Meeting, 2007.
• Ruffins SW, Lansford R, Martin M, Jacobs R, Fraser S, A mu MRI atlas of quail development, FASEB JOURNAL 21 (5): A201-A201 APR 2007.
• MacKenzie-Graham A, Aguilar C, Strickland LV, Morales L, Fubara B, Martin M, Jacobs R, Johnson GA, Toga A, Voskuhl R, Tiwari-Woodruff S. Purkinje Cell Death Underlies Grey Matter Atrophy in Experimental Autoimmune Encephalomyelitis, American Academy of Neurology, 2007.
• Martin M, Hiltner TD, Wood JC, Fraser SE, Jacobs RE, Readhead C. Myelin Deficiencies Visualized In Vivo: Visually Evoked Potentials and T2 weighted MR images of Shiverer Mutant and Wildtype Mice, Journal of Neuroscience Research, 84 (8), 1716-1726 (2006).
• MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis, Neuroimage 32, 2006, 1016-1023.
• Martin M, Kurjewicz LM, Readhead C, Using MRI as a Potential Diagnostic Tool in a Mouse Model of Alzheimer’s Disease. presentation at the Alzheimer Society 28th National Conference, November 2006, Toronto.
• MacKenzie-Graham AJ, Tinsley M, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl R, Toga AW, Cerebellar cortical atrophy in C57BL/6J mice with experimental autoimmune encephalomyelitis, Neurology 66 (5): A195-A195 Suppl. 2, 2006.
• Collister KA, Odero G, Martin M, Albensi BC. Visualization and correlations involving the deposition of amyloid beta plaques in the TgCRND8 mouse model of Alzheimer’s disease, Society for Neuroscience, 2006.
• Martin M, Chavakula V, Tyszka JM, Hiltner TD, Jacobs RE, Fraser SE, Readhead C, A Longitudinal Study Of A Mouse Model of Multiple Sclerosis, Journal of Neurochemistry, 96, Suppl 1, 59, 2006.
• Martin M, Chavakula V, Tyszka JM, Hiltner TD, Jacobs RE, Fraser SE, Readhead C, A Study Through The Disease Course Of A Mouse Model Of Multiple Sclerosis Using High-Resolution Magnetic Resonance Imaging And Visually Evoked Potential Measurements, Canadian Association of Physics Congress, 2006. 
• Jacobs EC, Pribyl TM, Kampf K, Campagnoni C, Messing A, Reyes SD, Martin M, Handley VW, Hiltner TD, Readhead C, Jacobs RE, Fisher RS, and Campagnoni AT. Region-specific myelin pathology in mice lacking the golli products of the Myelin Basic Protein gene, Journal of Neuroscience July 27, 2005 - 25(30):7004-7013. Erratum in: J Neurosci. 2005 Dec 14;25(50)
• Martin Mand Readhead R, In Vivo Beta-Amyloid Plaques Visualized through MRI in mouse model of Alzheimer’s Disease, Journal of Neurochemistry 2005, 94:23.
• Campagnoni AT, Jacobs EC, Pribyl TM, Kampf K, Campagnoni CW, Cowell CS, Reyes SD, Martin M, Handley VW, Hiltner TD, Readhead C, Jacobs RE, Messing A, and Fisher RS. Region-specific myelin pathology in mice lacking the golli products of the Myelin Basic Protein gene, Journal of Neurochemistry 2005, 94:106.
• Martin M, Reyes S, Tyszka JM, Fisher R, Campagnoni AT, Fraser SE, Jacobs RE, and Readhead C. T2-weighted In Vivo MRI and Visually Evoked Potential Measurements during the Development of Mice that Ectopically Over Express the J37 Golli Product of the MBP Gene in the Oligodendrocytes. Journal Of Neurochemistry 2004; 90:136.
• Martin M, Reyes SD, Fisher R, Campagnoni AT, Hiltner TD, Tyszka JM, Fraser SE, Jacobs RE and Readhead C. Visualizing Myelin Disorders In Vivo. Canadian Association of Physics Congress, Winnipeg, Canada, 2004.
• Martin M, Hiltner TD, Reyes SD, Tyszka JM, Fisher R, Campagnoni AT, Fraser SE, Jacobs RE and Readhead C. T2-weighted In Vivo MRI and Visually Evoked Potential Measurements during the Development of MBP::J37 Transgenic Mice. Journal Of Neurochemistry 2004; 90:5.